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Cerespectus is developing a minimally invasive, catheter-based platform for delivering gene therapies directly into the cerebrospinal fluid via lumbar access — a safer and more accessible alternative to current high-risk procedures. Their image-guided microcatheter enables real-time navigation to the cisterna magna, addressing a critical need in neurological drug delivery for conditions like Alzheimer’s, Parkinson’s, and rare pediatric diseases.

Lead Program & Pipeline

  • Lead product: Image-guided microcatheter system for CNS drug and gene therapy delivery

  • Targets cisterna magna through lumbar access, avoiding high-risk suboccipital puncture

  • Applicable to treatment of neurological and genetic disorders, including Alzheimer’s, Parkinson’s, GM1, and Hunter’s syndrome

  • Platform adaptable for broader cerebrospinal fluid (CSF) drug delivery use cases

Technology Differentiators

  • First device to reach cisterna magna via lumbar access, enabling safer delivery

  • Incorporates real-time video guidance for precise catheter placement

  • Minimally invasive, improves accessibility and reduces need for highly specialized training

  • Enables safer and more effective gene therapy infusions for both adult and pediatric populations

  • International patents filed (granted in Israel, under review in US and EU)

Stage & Investment

  • Stage: Preclinical

  • Funding Raised: <$500K

  • IP: International patents filed (US & EU under review, granted in Israel)

  • Regulatory: Aligned with FDA via Q-Sub; pursuing De Novo Class II designation

  • Collaborators: University of Pennsylvania, PCI Ventures, Synectic Engineering, Penn Health-Tech

What's Next

  • Finalize microcatheter and navigation system prototype

  • Conduct benchtop, cadaveric, and preclinical safety studies

  • Complete market and pricing research with neurologists and hospital stakeholders

  • Submit De Novo application to FDA

  • Open fundraising for next development phase, targeting $2M

Leadership

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Kamna Giare-Patel, MS
CEO & Co-founder
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Bryan Pukenas, MD
Co-founder
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